--- title: "New and sex-specific migraine susceptibility | Sutter Health" description: "This large multiethnic migraine study provides important information that may substantially improve our understanding of the etiology of migraine susceptibility" url: "https://www.sutterhealth.org/research/publications/new-sex-specific-migraine-susceptibility-1055312836" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. New and sex-specific migraine susceptibility # New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis Choquet H, Yin J, Jacobson AS, Horton BH, Hoffmann TJ, Jorgenson E, Avins AL, & Pressman AR _Commun Biol.4(1):864. doi: 10.1038/s42003-021-02356-y._ 2021-07-22 ## Abstract Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS1, PBRM1, and SLC25A21) specific to women. This large multiethnic migraine study provides important information that may substantially improve our understanding of the etiology of migraine susceptibility. [PubMed abstract](https://pubmed.ncbi.nlm.nih.gov/34294844/) ## Research topics - [Migraine](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Migraine%5C%22%22) - [Neurological Disorders](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Neurological+Disorders%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Neuropsychiatric update: neuroimaging schizophrenia.](https://www.sutterhealth.org/research/publications/neuropsychiatric-update-neuroimaging-1055312750) Psychopharmacol Bull. 2007;40(4):156-67. Neuropsychiatric update: neuroimaging schizophrenia. Kile SJ. Psychopharmacol Bull. 2007;40(4):156-67. Neuropsychiatric update: neuroimaging schizophrenia. Kile SJ. 2007 Jul 20 - Publication ### [Brain regions showing increased activation by threat-related words in panic disorder.](https://www.sutterhealth.org/research/publications/brainregionsshowingincreasedactivation-1055312756) Maddock RJ1, Buonocore MH, Kile SJ, Garrett AS. Author information 1Department of Radiology, University of California Davis, 4801 X St, Sacramento, California 95817, USA. rjmaddock@ucdaris.edu Neuroreport. 2003 Mar 2003 Mar 20 - Publication ### [Identification of short-term pharmacodynamic effects of interferon-beta-1a in multiple sclerosis subjects with broad- based phenotypic profiling.](https://www.sutterhealth.org/research/publications/pharmacodynamic-effects-interferon-beta-1a-ms-1055312290) Kantor AB, Deng J, Waubant E, Lin H, Becker CH, Lacy JR, Perrone AM, Bennett D, Goelz SE. J Neuroimmunol. 188(1-2):103-16. Epub 2007 Jul 5. 2007 Aug 01 - Publication ### [Alzheimer abnormalities of the amygdala with Klüver-Bucy syndrome symptoms: an amygdaloid variant of Alzheimer disease](https://www.sutterhealth.org/research/publications/alzheimer-abnormalities-of-the-amygdala-1055312743) Arch Neurol. 2009 Jan;66(1):125-9. doi: 10.1001/archneurol.2008.517. Alzheimer abnormalities of the amygdala with Klüver-Bucy syndrome symptoms: an amygdaloid variant of Alzheimer disease. Kile SJ1, Ellis WG, Olichney JM, Farias S, DeCarli C. Author information 1Department of Neurology, University of California at Davis Arch Neurol. 2009 Jan; 2009 Jan 20 - Publication ### [Prevalence of migraine in a diverse community--electronic methods for migraine ascertainment in a large integrated health plan.](https://www.sutterhealth.org/research/publications/migraine-prevalence-through-ehrs-large-health-plan-1055312704) Pressman A, Jacobson A, Eguilos R, Gelfand A, Huynh C, Hamilton L, Avins A, Bakshi N, Merikangas K. Cephalalgia. 36(4):325-34. doi: 10.1177/0333102415590242. Epub 2015 Jun 11. 2016 Apr 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/new-sex-specific-migraine-susceptibility-1055312836#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"New and sex-specific migraine susceptibility"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/new-sex-specific-migraine-susceptibility-1055312836#medicalscholarlyarticle","name":"New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis","headline":"New and sex-specific migraine susceptibility","abstract":"Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS1, PBRM1, and SLC25A21) specific to women. 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