--- title: "New therapies for chronic obstructive pulmonary disease. | Sutter Health" description: "We discuss novel therapeutic options and future research directions that may have an impact on COPD mgmt." url: "https://www.sutterhealth.org/research/publications/new-therapies-copd-1055312955" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. New therapies for chronic obstructive pulmonary disease. # New therapies for chronic obstructive pulmonary disease. Krishna G, Sankaranarayanan V, & Chitkara RK. _Expert Opin Investig Drugs. 13(3):255-67._ 2004-03-01 ## Abstract Chronic obstructive pulmonary disease (COPD) is the most common lung disease, carrying a significant mortality and morbidity. None of the therapeutic interventions currently available alter the progression of the disease. As our understanding of the basic mechanisms of alveolar destruction and airflow limitation improves, new targets are identified that may eventually result in treatment options which will affect the progression of this disease. In this review, we discuss some of the novel therapeutic options recently developed that may have an impact on the management of COPD. Future directions in research and development of pharmacological agents based on improved understanding of COPD are also discussed. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/15013944) ![Ganesh Krishna, M.D., FCCP](https://dyn.mktgcdn.com/p/7HZoN6h0d4phO4VQYcU6TE-_Cn72_cBpIS3NRGru51E/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Ganesh Krishna, M.D., FCCP Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082) ## Research topics - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) - [Lung Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Lung+Diseases%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [A 35-year-old man with fever, dyspnea, and diffuse reticular opacities.](https://www.sutterhealth.org/research/publications/35-yo-man-fever-dyspnea-reticular-oopacities-1055312816) Katikireddy CK, Krishna G, Keifer T, Kuschner W, Rosen G. Chest. 129(2):482-7. 2006 Feb 01 - Publication ### [Effect of endobronchial coils vs usual care on exercise tolerance in patients with severe emphysema: the RENEW randomized clinical trial.](https://www.sutterhealth.org/research/publications/endobronchial-coils-severe-emphysema-trial-1055312472) Sciurba FC, Criner GJ, Strange C, Shah PL, Michaud G, Connolly TA, Deslée G, Tillis WP, Delage A, Marquette CH, Krishna G, Kalhan R, Ferguson JS, Jantz M, Maldonado F, McKenna R, Majid A, Rai N, Gay S, Dransfield MT, Angel L, Maxfield R, Herth FJ, Wahidi MM, Mehta A, Slebos DJ; RENEW Study Research Group. JAMA. 315(20):2178-2189. doi: 10.1001/jama.2016.6261. 2016 May 24 - Publication ### [A 24-year-old woman with bilateral pulmonary infiltrates, pericardial effusion, and bilateral pleural effusions.](https://www.sutterhealth.org/research/publications/24-yo-woman-pulmonary-infiltrates-effusions-1055312831) Katikireddy CK, Krishna G, Berry G, Faul J, Kuschner W. Chest. 128(6):4013-7. 2005 Dec 01 - Publication ### [The dying thoracic patient.](https://www.sutterhealth.org/research/publications/dying-thoracic-patient-1055312967) Krishna G, Raffin TA. Chest Surg Clin N Am. 8(3):723-39. 1998 Aug 01 - Publication ### [Advances in the management of chronic obstructive pulmonary disease.](https://www.sutterhealth.org/research/publications/advances-mgmt-copd-1055312934) Meinke L, Chitkara R, Krishna G. Expert Opin Pharmacother. 8(1):23-37. 2007 Jan 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/new-therapies-copd-1055312955#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"New therapies for chronic obstructive pulmonary disease."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/new-therapies-copd-1055312955#medicalscholarlyarticle","name":"New therapies for chronic obstructive pulmonary disease.","headline":"New therapies for chronic obstructive pulmonary disease.","abstract":"Chronic obstructive pulmonary disease (COPD) is the most common lung disease, carrying a significant mortality and morbidity. 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