--- title: "Single-blastocyst transfer & maternal and neonatal outcome. | Sutter Health" description: "Frozen-thawed BT is associated with improved general perinatal outcomes of pregnancy but significantly increased maternal risks of placenta accreta and PIH." url: "https://www.sutterhealth.org/research/publications/one-blastocyst-transfer-matern-infant-outcome-1055312440" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Single-blastocyst transfer & maternal and neonatal outcome. # Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Ishihara O, Araki R, Kuwahara A, Itakura A, Saito H, & Adamson GD. _Fertil Steril. 101(1):128-33. doi: 10.1016/j.fertnstert.2013.09.025. Epub 2013 Oct 23._ 2014-01-01 ## Abstract OBJECTIVE: To evaluate the relationship between frozen-thawed single blastocyst transfer (BT) and maternal and neonatal outcomes of pregnancy. DESIGN: Retrospective analysis. SETTING: Japanese nationwide registry of assisted reproductive technology (ART) with mandatory reporting for all ART clinics in Japan. PATIENT(S): Registered from 2008 through 2010 undergoing single embryo transfer cycles (n = 277,042). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Rates of preterm birth (PTB; <37 weeks' gestation), low birth weight (LBW; <2,500 g), small for gestational age (SGA), large for gestational age (LGA), placenta previa, placenta abruption, placenta accreta, and pregnancy-induced hypertension (PIH) after fresh/frozen-thawed and cleaved-embryo/blastocyst transfers were performed. RESULT(S): Frozen-thawed embryo transfer (FET) was associated with a significantly reduced occurrence of PTB, LBW, and SGA but increased rate of LGA. FET was also associated with a higher incidence of placenta accreta (odds ratio 3.16) and PIH (odds ratio 1.58). BT was associated with a significantly decreased rate of SGA and increased rate of LGA. There was no significant association between BT and maternal complications. CONCLUSION(S): Frozen-thawed BT is associated with improved general perinatal outcomes of pregnancy but significantly increased maternal risks of placenta accreta and PIH. This finding requires further investigation to assure maternal safety of patients undergoing ART treatment. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/24268706) ## Research topics - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) - [Maternal and Infant Health](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Maternal+and+Infant+Health%5C%22%22) - [Obstetrics and Gynecology](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Obstetrics+and+Gynecology%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2011.](https://www.sutterhealth.org/research/publications/world-report-on-assisted-reproductive-technology-2011-1055312366) Adamson GD, de Mouzon J, Chambers GM, Zegers-Hochschild F, Mansour R, Ishihara O, Banker M, Dyer S. Fertil Steril. 110(6):1067-1080. doi: 10.1016/j.fertnstert.2018.06.039. 2018 Nov 01 - Publication ### [World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research.](https://www.sutterhealth.org/research/publications/fluid-biospec-collect-process-store-endomet-res-1055312426) Rahmioglu N, Fassbender A, Vitonis AF, Tworoger SS, Hummelshoj L, D'Hooghe TM, Adamson GD, Giudice LC, Becker CM, Zondervan KT, Missmer SA; WERF EPHect Working Group. Fertil Steril. 2014 Nov;102(5):1233-43. doi: 10.1016/j.fertnstert.2014.07.1208. Epub 2014 Sep 22. 2014 Nov 01 - Publication ### [Improved implantation rates of day 3 embryo transfers with the use of an automated time-lapse-enabled test to aid in embryo selection.](https://www.sutterhealth.org/research/publications/improved-implantation-rates-day-3-embryo-transfers-1055312301) Adamson GD, Abusief ME, Palao L, Witmer J, Palao LM, Gvakharia M. Fertil Steril. pii: S0015-0282(15)02041-5. doi: 10.1016/j.fertnstert.2015.10.030. \[Epub ahead of print\] 2015 Nov 18 - Publication ### [Research priorities for endometriosis: recommendations from a global consortium of investigators in endometriosis.](https://www.sutterhealth.org/research/publications/research-priorities-endometriosis-1055312479) Rogers PA, Adamson GD, Al-Jefout M, Becker CM, D'Hooghe TM, Dunselman GA, Fazleabas A, Giudice LC, Horne AW, Hull ML, Hummelshoj L, Missmer SA, Montgomery GW, Stratton P, Taylor RN, Rombauts L, Saunders PT, Vincent K, Zondervan KT; WES/WERF Consortium for Research Priorities in Endometriosis. Reprod Sci. pii: 1933719116654991. \[Epub ahead of print\] 2016 Jun 30 - Publication ### [World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research.](https://www.sutterhealth.org/research/publications/tissue-collectn-process-storage-endometriosis-res-1055312412) Fassbender A, Rahmioglu N, Vitonis AF, Viganò P, Giudice LC, D'Hooghe TM, Hummelshoj L, Adamson GD, Becker CM, Missmer SA, Zondervan KT; WERF EPHect Working Group. Fertil Steril. 102(5):1244-53. doi: 10.1016/j.fertnstert.2014.07.1209. Epub 2014 Sep 22. 2014 Nov 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/one-blastocyst-transfer-matern-infant-outcome-1055312440#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Single-blastocyst transfer & maternal and neonatal outcome."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/one-blastocyst-transfer-matern-infant-outcome-1055312440#medicalscholarlyarticle","name":"Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan.","headline":"Single-blastocyst transfer & maternal and neonatal outcome.","abstract":"OBJECTIVE: To evaluate the relationship between frozen-thawed single blastocyst transfer (BT) and maternal and neonatal outcomes of pregnancy. DESIGN: Retrospective analysis. SETTING: Japanese nationwide registry of assisted reproductive technology (ART) with mandatory reporting for all ART clinics in Japan. PATIENT(S): Registered from 2008 through 2010 undergoing single embryo transfer cycles (n = 277,042). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Rates of preterm birth (PTB; \u003c37 weeks' gestation), low birth weight (LBW; \u003c2,500 g), small for gestational age (SGA), large for gestational age (LGA), placenta previa, placenta abruption, placenta accreta, and pregnancy-induced hypertension (PIH) after fresh/frozen-thawed and cleaved-embryo/blastocyst transfers were performed. RESULT(S): Frozen-thawed embryo transfer (FET) was associated with a significantly reduced occurrence of PTB, LBW, and SGA but increased rate of LGA. FET was also associated with a higher incidence of placenta accreta (odds ratio 3.16) and PIH (odds ratio 1.58). BT was associated with a significantly decreased rate of SGA and increased rate of LGA. There was no significant association between BT and maternal complications. CONCLUSION(S): Frozen-thawed BT is associated with improved general perinatal outcomes of pregnancy but significantly increased maternal risks of placenta accreta and PIH. This finding requires further investigation to assure maternal safety of patients undergoing ART treatment.","description":"Frozen-thawed BT is associated with improved general perinatal outcomes of pregnancy but significantly increased maternal risks of placenta accreta and PIH.","keywords":["Disease Management","Maternal and Infant Health","Obstetrics and Gynecology"],"datePublished":"2014-01-01","url":"https://www.sutterhealth.org/research/publications/one-blastocyst-transfer-matern-infant-outcome-1055312440","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"PMID","value":"24268706"},{"@type":"PropertyValue","propertyID":"DOI","value":"10.1016/j.fertnstert.2013.09.025"}],"sameAs":["https://pubmed.ncbi.nlm.nih.gov/24268706/","https://doi.org/10.1016/j.fertnstert.2013.09.025"],"isPartOf":{"@type":"Periodical","name":"Fertil Steril"},"author":[{"@type":"Person","name":"Ishihara O"},{"@type":"Person","name":"Araki R"},{"@type":"Person","name":"Kuwahara A"},{"@type":"Person","name":"Itakura A"},{"@type":"Person","name":"Saito H"},{"@type":"Person","name":"Adamson GD"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Disease Management","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Disease+Management%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Maternal and Infant Health","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Maternal+and+Infant+Health%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Obstetrics and Gynecology","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Obstetrics+and+Gynecology%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/one-blastocyst-transfer-matern-infant-outcome-1055312440","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/one-blastocyst-transfer-matern-infant-outcome-1055312440#breadcrumblist"}}} ```