--- title: "Outer vol suppressn & T2 prep sequence: ht angiography. | Sutter Health" description: "OVS-T2 Prep is a compact sequence: can accelerate coronary MRA by suppressing signals from tissues surrounding the heart while enhancing blood-myocard contrast." url: "https://www.sutterhealth.org/research/publications/outer-vol-suppressn-t2-prepseq-ht-angiography-1055312448" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Outer vol suppressn & T2 prep sequence: ht angiography. # Combined outer volume suppression and T2 preparation sequence for coronary angiography. Luo J, Addy NO, Ingle RR, Hargreaves BA, Hu BS, Nishimura DG, & Shin T. _Magn Reson Med. 74(6):1632-9. doi: 10.1002/mrm.25575. Epub 2014 Dec 17._ 2015-12-01 ## Abstract ****PURPOSE:**** To develop a magnetization preparation sequence for simultaneous outer volume suppression (OVS) and T2 weighting in whole-heart coronary magnetic resonance angiography. ****METHODS:**** A combined OVS and T2 preparation sequence (OVS-T2 Prep) was designed with a nonselective adiabatic 90° tipdown pulse, two adiabatic 180° refocusing pulses, and a 2D spiral -90° tipup pulse. The OVS-T2 Prep preserves the magnetization inside an elliptic cylinder with T2 weighting, while saturating the magnetization outside the cylinder. Its performance was tested on phantoms and on 13 normal subjects with coronary magnetic resonance angiography using 3D cones trajectories. ****RESULTS:**** Phantom studies showed expected T2 -dependent signal amplitude in the spatial passband and suppressed signal in the spatial stopband. In vivo studies with full-field-of-view cones yielded a passband-to-stopband signal ratio of 3.18 ± 0.77 and blood-myocardium contrast-to-noise ratio enhancement by a factor of 1.43 ± 0.20 (P < 0.001). In vivo studies with reduced-field-of-view cones showed that OVS-T2 Prep well suppressed the aliasing artifacts, as supported by significantly reduced signal in the regions with no tissues compared to the images acquired without preparation (P < 0.0001). ****CONCLUSION:**** OVS-T2 Prep is a compact sequence that can accelerate coronary magnetic resonance angiography by suppressing signals from tissues surrounding the heart while simultaneously enhancing the blood-myocardium contrast. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/25521477) ![Bob S Hu, M.D.](https://dyn.mktgcdn.com/p/OLtyV-80yDbOmh0GcQI3xnNzxEtgLP1RmJcZvvKP3u4/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Bob S Hu, M.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033) ## Research topics - [Cardiovascular Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Cardiovascular+Diseases%5C%22%22) - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [3D image-based navigators for coronary MR angiography.](https://www.sutterhealth.org/research/publications/3d-image-navig-ht-mr-angiography-1055312459) Addy NO, Ingle RR, Luo J, Baron CA, Yang PC, Hu BS, Nishimura DG. Magn Reson Med. doi: 10.1002/mrm.26269. \[Epub ahead of print\] 2016 May 13 - Publication ### [Cardiovascular magnetic resonance phase contrast imaging.](https://www.sutterhealth.org/research/publications/cardiovasc-mri-phase-contrast-1055312458) Nayak KS, Nielsen JF, Bernstein MA, Markl M, D Gatehouse P, M Botnar R, Saloner D, Lorenz C, Wen H, S Hu B, Epstein FH, N Oshinski J, Raman SV. J Cardiovasc Magn Reson. 17(1):71. doi: 10.1186/s12968-015-0172-7. 2015 Aug 09 - Publication ### [High-resolution variable-density 3D cones coronary MRA.](https://www.sutterhealth.org/research/publications/high-resolution-vary-density-3d-cones-coronary-mra-1055312425) Addy NO, Ingle RR, Wu HH, Hu BS, Nishimura DG. Magn Reson Med. 74(3):614-21. doi: 10.1002/mrm.25803. Epub 2015 Jul 14. 2015 Sep 01 - Publication ### [Off-resonance-robust velocity-selective magnetization preparation for non-contrast-enhanced peripheral MR angiography.](https://www.sutterhealth.org/research/publications/off-reson-robust-veloc-select-magnetiz-prep-mra-1055312480) Shin T, Hu BS, Nishimura DG. Magn Reson Med. 70(5):1229-40. doi: 10.1002/mrm.24561. Epub 2012 Nov 28. 2013 Nov 01 - Publication ### [Nonrigid autofocus motion correction for coronary MR angiography with a 3D cones trajectory.](https://www.sutterhealth.org/research/publications/nonrigid-autofocus-motion-correctn-ht-mra-1055312469) Ingle RR, Wu HH, Addy NO, Cheng JY, Yang PC, Hu BS, Nishimura DG. Magn Reson Med. 72(2):347-61. doi: 10.1002/mrm.24924. Epub 2013 Sep 4. 2014 Aug 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/outer-vol-suppressn-t2-prepseq-ht-angiography-1055312448#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Outer vol suppressn & T2 prep sequence: ht angiography."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/outer-vol-suppressn-t2-prepseq-ht-angiography-1055312448#medicalscholarlyarticle","name":"Combined outer volume suppression and T2 preparation sequence for coronary angiography.","headline":"Outer vol suppressn & T2 prep sequence: ht angiography.","abstract":"PURPOSE: To develop a magnetization preparation sequence for simultaneous outer volume suppression (OVS) and T2 weighting in whole-heart coronary magnetic resonance angiography. METHODS: A combined OVS and T2 preparation sequence (OVS-T2 Prep) was designed with a nonselective adiabatic 90° tipdown pulse, two adiabatic 180° refocusing pulses, and a 2D spiral -90° tipup pulse. The OVS-T2 Prep preserves the magnetization inside an elliptic cylinder with T2 weighting, while saturating the magnetization outside the cylinder. Its performance was tested on phantoms and on 13 normal subjects with coronary magnetic resonance angiography using 3D cones trajectories. RESULTS: Phantom studies showed expected T2 -dependent signal amplitude in the spatial passband and suppressed signal in the spatial stopband. In vivo studies with full-field-of-view cones yielded a passband-to-stopband signal ratio of 3.18 ± 0.77 and blood-myocardium contrast-to-noise ratio enhancement by a factor of 1.43 ± 0.20 (P \u003c 0.001). In vivo studies with reduced-field-of-view cones showed that OVS-T2 Prep well suppressed the aliasing artifacts, as supported by significantly reduced signal in the regions with no tissues compared to the images acquired without preparation (P \u003c 0.0001). CONCLUSION: OVS-T2 Prep is a compact sequence that can accelerate coronary magnetic resonance angiography by suppressing signals from tissues surrounding the heart while simultaneously enhancing the blood-myocardium contrast.","description":"OVS-T2 Prep is a compact sequence: can accelerate coronary MRA by suppressing signals from tissues surrounding the heart while enhancing blood-myocard contrast.","keywords":["Cardiovascular Diseases","Disease Management"],"datePublished":"2015-12-01","url":"https://www.sutterhealth.org/research/publications/outer-vol-suppressn-t2-prepseq-ht-angiography-1055312448","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"PMID","value":"25521477"},{"@type":"PropertyValue","propertyID":"DOI","value":"10.1002/mrm.25575"}],"sameAs":["https://pubmed.ncbi.nlm.nih.gov/25521477/","https://doi.org/10.1002/mrm.25575"],"isPartOf":{"@type":"Periodical","name":"Magn Reson Med"},"author":[{"@type":"Person","name":"Luo J"},{"@type":"Person","name":"Addy NO"},{"@type":"Person","name":"Ingle RR"},{"@type":"Person","name":"Hargreaves BA"},{"@type":"Person","@id":"https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033","name":"Hu BS","url":"https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033"},{"@type":"Person","name":"Nishimura DG"},{"@type":"Person","name":"Shin T"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Cardiovascular Diseases","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Cardiovascular+Diseases%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Disease Management","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Disease+Management%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/outer-vol-suppressn-t2-prepseq-ht-angiography-1055312448","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/outer-vol-suppressn-t2-prepseq-ht-angiography-1055312448#breadcrumblist"}}} ```