--- title: "Oxalate transport in cultured porcine renal epithelial cells | Sutter Health" description: "Oxalate transport in cultured porcine renal epithelial cells." url: "https://www.sutterhealth.org/research/publications/oxalate-transport-in-cultured-porcine-renal-epithe-1055312722" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Oxalate transport in cultured porcine renal epithelial cells # Oxalate transport in cultured porcine renal epithelial cells. T R Wandzilak 1, L Calo, S D'Andre, A Borsatti, & H E Williams _T R Wandzilak 1_ _L Calo_ _S D'Andre_ _A Borsatti_ _H E Williams_ 1992-07-20 ## Abstract Oxalate-containing kidney stones are the most common type (75%) of renal stones. In order to control oxalate excretion in the urine, a basic understanding of the cellular transport of oxalate is imperative. We have utilized the technique of continuous cell culture to establish and characterize a model system to study renal epithelial cell (LLCPK1) oxalate transport. Our data demonstrate that oxalate uptake in these cells is dependent on time, concentration and energy. The Km for oxalate uptake was 200 microM. Oxalate uptake was decreased at lower temperatures and elevated in an acidic extracellular environment. Both anion exchange inhibitors DIDS and SITS inhibited oxalate uptake. Sulfate, chloride, and bicarbonate decreased oxalate uptake, as did the diuretics bumetanide and furosemide. There was no evidence for the co-transport of oxalate with sodium. Our data show that monolayers of cultured kidney epithelial cells are a valuable model system for study of the basic cellular mechanisms of oxalate transport. [PubMed abstract](https://pubmed.ncbi.nlm.nih.gov/1455566/) ## Research topics - [All Cancer](https://www.sutterhealth.org/research-search-results?query=%22%5C%22All+Cancer%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Breast Cancer Subtypes as Defined by the Estrogen Receptor (ER), Progesterone Receptor (PR), and the Human Epidermal Growth Factor Receptor 2 (HER2) among Women with Invasive Breast Cancer in California](https://www.sutterhealth.org/research/publications/breast-cancer-subtypes-as-defined-by-the-estrogen-1055312635) 1999-2004. Breast J. November/December 2009;15(6):593-602. 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J Womens Health Gend Based Med. 2002 Apr;11(3):291-301. 2002 Apr 20 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/oxalate-transport-in-cultured-porcine-renal-epithe-1055312722#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Oxalate transport in cultured porcine renal epithelial cells"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/oxalate-transport-in-cultured-porcine-renal-epithe-1055312722#medicalscholarlyarticle","name":"Oxalate transport in cultured porcine renal epithelial cells.","headline":"Oxalate transport in cultured porcine renal epithelial cells","abstract":"Oxalate-containing kidney stones are the most common type (75%) of renal stones. 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