--- title: "rapid-3d-gadolinium-enhancemt-cardiac-mri | Sutter Health" description: "Stack-of-spiral acquisition combined with non-Cartesian SPIRiT parallel imaging enables rapid 3D LGE MRI in a 12 heartbeat-long breath-hold." url: "https://www.sutterhealth.org/research/publications/rapid-3d-gadolinium-enhancemt-cardiac-mri-1055312461" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. rapid-3d-gadolinium-enhancemt-cardiac-mri # Rapid single-breath-hold 3D late gadolinium enhancement cardiac MRI using a stack-of-spirals acquisition. Shin T, Lustig M, Nishimura DG, & Hu BS. _J Magn Reson Imaging. 40(6):1496-502. doi: 10.1002/jmri.24494. Epub 2013 Nov 15. J Magn Reson Imaging. 40(6):1496-502. doi: 10.1002/jmri.24494. Epub 2013 Nov 15. Send to:_ 2014-12-02 ## Abstract PURPOSE: To develop a rapid single-breath-hold 3D late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) method, and demonstrate its feasibility in cardiac patients. MATERIALS AND METHODS: An inversion recovery dual-density 3D stack-of-spirals imaging sequence was developed. The spiral acquisition was 2-fold accelerated by self-consistent parallel imaging reconstruction (SPIRiT), which resulted in a total scan time of 12 heartbeats. Field map-based linear off-resonance correction was incorporated to the SPIRiT reconstruction. The 3D spiral LGE scans were performed in 15 patients who were referred for clinically ordered cardiac MR examinations that included the standard 2D multislice LGE imaging. Image sharpness and overall quality were qualitatively assessed based on 5-point scales. RESULTS: Scar-induced hyper-LGE was identified in 4 out of the 15 patients by both 3D spiral and 2D multislice LGE tests. On average over all datasets (n = 15), the image sharpness scores were 3.9 (3D spiral) and 4.0 (2D multislice), and the image quality scores were 4.1 (3D spiral) and 4.0 (2D multislice) with no significant difference in both metrics (paired t-test; P > 0.1). The average scar contrast enhancement ratios were 0.72 and 0.75 in 3D and 2D images, respectively (n = 4). The average difference of fractional scar volumes measured in 3D and 2D images was 4.3% (n = 3). CONCLUSION: Stack-of-spiral acquisition combined with non-Cartesian SPIRiT parallel imaging enables rapid 3D LGE MRI in a 12 heartbeat-long breath-hold. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/24243575) ![Bob S Hu, M.D.](https://dyn.mktgcdn.com/p/OLtyV-80yDbOmh0GcQI3xnNzxEtgLP1RmJcZvvKP3u4/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Bob S Hu, M.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033) ## Research topics - [Cardiovascular Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Cardiovascular+Diseases%5C%22%22) - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Nonrigid autofocus motion correction for coronary MR angiography with a 3D cones trajectory.](https://www.sutterhealth.org/research/publications/nonrigid-autofocus-motion-correctn-ht-mra-1055312469) Ingle RR, Wu HH, Addy NO, Cheng JY, Yang PC, Hu BS, Nishimura DG. Magn Reson Med. 72(2):347-61. doi: 10.1002/mrm.24924. Epub 2013 Sep 4. 2014 Aug 01 - Publication ### [Whole-heart coronary MR angiography using a 3D cones phyllotaxis trajectory.](https://www.sutterhealth.org/research/publications/whole-heart-coronary-mr-angiography-1055312405) Malavé MO, Baron CA, Addy NO, Cheng JY, Yang PC, Hu BS, Nishimura DG. Magn Reson Med. doi: 10.1002/mrm.27475. \[Epub ahead of print\] 2018 Oct 29 - Publication ### [Health status after transcatheter aortic valve replacement in patients at extreme surgical risk: results from the CoreValve U.S. trial.](https://www.sutterhealth.org/research/publications/health-status-post-tavr-corevalve-us-trial-1055312500) Osnabrugge RL, Arnold SV, Reynolds MR, Magnuson EA, Wang K, Gaudiani VA, Stoler RC, Burdon TA, Kleiman N, Reardon MJ, Adams DH, Popma JJ, Cohen DJ; CoreValve U.S. Trial Investigators. JACC Cardiovasc Interv. 8(2):315-23. doi: 10.1016/j.jcin.2014.08.016. 2015 Feb 01 - Publication ### [Off-resonance-robust velocity-selective magnetization preparation for non-contrast-enhanced peripheral MR angiography.](https://www.sutterhealth.org/research/publications/off-reson-robust-veloc-select-magnetiz-prep-mra-1055312480) Shin T, Hu BS, Nishimura DG. Magn Reson Med. 70(5):1229-40. doi: 10.1002/mrm.24561. Epub 2012 Nov 28. 2013 Nov 01 - Publication ### [Nonrigid motion correction with 3D image-based navigators for coronary MR angiography.](https://www.sutterhealth.org/research/publications/motion-correction-3d-image-navig-ht-mra-1055312449) Luo J, Addy NO, Ingle RR, Baron CA, Cheng JY, Hu BS, Nishimura DG. Magn Reson Med. doi: 10.1002/mrm.26273. \[Epub ahead of print\] 2016 May 13 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/rapid-3d-gadolinium-enhancemt-cardiac-mri-1055312461#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"rapid-3d-gadolinium-enhancemt-cardiac-mri"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/rapid-3d-gadolinium-enhancemt-cardiac-mri-1055312461#medicalscholarlyarticle","name":"Rapid single-breath-hold 3D late gadolinium enhancement cardiac MRI using a stack-of-spirals acquisition.","headline":"rapid-3d-gadolinium-enhancemt-cardiac-mri","abstract":"PURPOSE: To develop a rapid single-breath-hold 3D late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) method, and demonstrate its feasibility in cardiac patients. MATERIALS AND METHODS: An inversion recovery dual-density 3D stack-of-spirals imaging sequence was developed. The spiral acquisition was 2-fold accelerated by self-consistent parallel imaging reconstruction (SPIRiT), which resulted in a total scan time of 12 heartbeats. Field map-based linear off-resonance correction was incorporated to the SPIRiT reconstruction. The 3D spiral LGE scans were performed in 15 patients who were referred for clinically ordered cardiac MR examinations that included the standard 2D multislice LGE imaging. Image sharpness and overall quality were qualitatively assessed based on 5-point scales. RESULTS: Scar-induced hyper-LGE was identified in 4 out of the 15 patients by both 3D spiral and 2D multislice LGE tests. On average over all datasets (n = 15), the image sharpness scores were 3.9 (3D spiral) and 4.0 (2D multislice), and the image quality scores were 4.1 (3D spiral) and 4.0 (2D multislice) with no significant difference in both metrics (paired t-test; P > 0.1). The average scar contrast enhancement ratios were 0.72 and 0.75 in 3D and 2D images, respectively (n = 4). The average difference of fractional scar volumes measured in 3D and 2D images was 4.3% (n = 3). CONCLUSION: Stack-of-spiral acquisition combined with non-Cartesian SPIRiT parallel imaging enables rapid 3D LGE MRI in a 12 heartbeat-long breath-hold.","description":"Stack-of-spiral acquisition combined with non-Cartesian SPIRiT parallel imaging enables rapid 3D LGE MRI in a 12 heartbeat-long breath-hold.","keywords":["Cardiovascular Diseases","Disease Management"],"datePublished":"2014-12-02","url":"https://www.sutterhealth.org/research/publications/rapid-3d-gadolinium-enhancemt-cardiac-mri-1055312461","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"PMID","value":"24243575"},{"@type":"PropertyValue","propertyID":"DOI","value":"10.1002/jmri.24494"}],"sameAs":["https://pubmed.ncbi.nlm.nih.gov/24243575/","https://doi.org/10.1002/jmri.24494"],"isPartOf":{"@type":"Periodical","name":"J Magn Reson Imaging"},"author":[{"@type":"Person","name":"Shin T"},{"@type":"Person","name":"Lustig M"},{"@type":"Person","name":"Nishimura DG"},{"@type":"Person","@id":"https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033","name":"Hu BS","url":"https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Cardiovascular Diseases","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Cardiovascular+Diseases%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Disease Management","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Disease+Management%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/rapid-3d-gadolinium-enhancemt-cardiac-mri-1055312461","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/rapid-3d-gadolinium-enhancemt-cardiac-mri-1055312461#breadcrumblist"}}} ```