--- title: "Risk of incident disease after dx of chronic rhinosinusitis. | Sutter Health" description: "Study suggests either that chronic rhinosinusitis promotes onset of other diseases or is an indicator of systemic disease processes." url: "https://www.sutterhealth.org/research/publications/risk-of-incident-disease-after-dx-of-chronic-rhinosinusitis-1055312747" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Risk of incident disease after dx of chronic rhinosinusitis. # Five-year risk of incident disease following a diagnosis of chronic rhinosinusitis. Hirsch AG, Yan XS, Sundaresan AS, Tan BK, Schleimer RP, Kern RC, Kennedy TL, Greene JS, & Schwartz BS. _Allergy. 70(12):1613-21. doi: 10.1111/all.12759. Epub 2015 Sep 25._ 2015-12-01 ## Abstract BACKGROUND: Chronic rhinosinusitis (CRS) has a broad range of comorbidities. Due to a lack of longitudinal studies, it is not known whether these comorbidities cause CRS, are promoted by CRS, or share a systemic disease process with CRS.OBJECTIVE: The objective of this study was to determine the risk of incident disease within 5 years after a new diagnosis of CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). METHODS: We conducted a case-control study nested within the longitudinal cohort of primary care patients in the Geisinger Clinic using electronic health record data. We evaluated incident disease over 5 years in newly diagnosed CRSwNP and CRSsNP cases compared to controls using multivariable Cox regression models. RESULTS: CRSsNP (n = 3612) cases were at greater risk (HR, 95% confidence interval) than controls for incidence of: upper airway diseases, including adenotonsillitis (3.29, 2.41-4.50); lower aerodigestive tract diseases, including asthma (2.69, 2.14-3.38); epithelial conditions, including atopic dermatitis (2.75, 1.23-6.16); and hypertension (1.38, 1.19-1.61). CRSwNP (n = 241) cases were at greater risk for obesity than controls (1.74, 1.08-2.80), but CRSwNP was not associated with other diseases. CONCLUSION: The risk of other diseases associated with CRS adds to the burden of an already highly burdensome condition, and suggests either that CRS promotes onset of other diseases or is an indicator of systemic disease processes. Different patterns of association with diseases by CRS phenotype may be due to CRSwNP sample size limitations or reflect a different pattern of disease onset by phenotype. These findings have implications for screening guidelines and care of CRS patients. [PubMed abstract](https://www.ncbi.nlm.nih.gov/pubmed/?term=hirsch+ag%2C+yan+x%2C+sundaresan+as) ![Xiaowei (Sherry) Yan, Ph.D.](https://dyn.mktgcdn.com/p/NTWox_hkmxIRiqJEc5PXKeBkfR_WMtpSQbEI4J69Xls/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Xiaowei (Sherry) Yan, Ph.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/xiaowei-sherry-yan-phd-1049681042) ## Research topics - [Asthma](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Asthma%5C%22%22) - [General Cardiology](https://www.sutterhealth.org/research-search-results?query=%22%5C%22General+Cardiology%5C%22%22) - [Infectious Disease](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Infectious+Disease%5C%22%22) - [Obesity](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Obesity%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Obesity, insulin resistance and the prevalence of atopy and asthma in US adults.](https://www.sutterhealth.org/research/publications/obesity-insulin-resistance-atopy-asthma-adults-1055312557) Ma J, Xiao L, Knowles SB. Allergy. 65(11):1455-63. doi: 10.1111/j.1398-9995.2010.02402.x. 2010 Nov 01 - Publication ### [Abdominal and general adiposity and level of asthma control in adults with uncontrolled asthma.](https://www.sutterhealth.org/research/publications/adiposity-and-level-of-asthma-control-1055312908) Lv N, Xiao L, Camargo CA Jr, Wilson SR, Buist AS, Strub P, Nadeau KC, Ma J. Ann Am Thorac Soc. 11(8):1218-24. doi: 10.1513/AnnalsATS.201405-214OC. 2014 Oct 01 - Publication ### [Weight management interventions in adult and pediatric asthma populations: a systematic review.](https://www.sutterhealth.org/research/publications/wt-mgmt-adult-ped-asthma-review-1055312799) Lv N, Xiao L, Ma J. J Pulm Respir Med. 5:232. doi:10.4172/2161-105X.1000232 2014 Dec 26 - Publication ### [Weight management interventions in adult and pediatric asthma populations: a systematic review.](https://www.sutterhealth.org/research/publications/weight-mgmt-interventions-asthma-review-1055312909) Lv N, Xiao L, Ma J. J Pulm Respir Med. 5(232). pii: 1000232. 2015 Oct 01 - Publication ### [Association of general and central obesity and atopic and nonatopic asthma in US adults.](https://www.sutterhealth.org/research/publications/obesity-atopic-nonatopic-asthma-in-us-adults-1055312601) Ma J, Xiao L. J Asthma. 50(4):395-402. doi: 10.3109/02770903.2013.770014. Epub 2013 Feb 25. 2013 May 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/risk-of-incident-disease-after-dx-of-chronic-rhinosinusitis-1055312747#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Risk of incident disease after dx of chronic rhinosinusitis."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/risk-of-incident-disease-after-dx-of-chronic-rhinosinusitis-1055312747#medicalscholarlyarticle","name":"Five-year risk of incident disease following a diagnosis of chronic rhinosinusitis.","headline":"Risk of incident disease after dx of chronic rhinosinusitis.","abstract":"BACKGROUND: Chronic rhinosinusitis (CRS) has a broad range of comorbidities. Due to a lack of longitudinal studies, it is not known whether these comorbidities cause CRS, are promoted by CRS, or share a systemic disease process with CRS.OBJECTIVE: The objective of this study was to determine the risk of incident disease within 5 years after a new diagnosis of CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). METHODS: We conducted a case-control study nested within the longitudinal cohort of primary care patients in the Geisinger Clinic using electronic health record data. We evaluated incident disease over 5 years in newly diagnosed CRSwNP and CRSsNP cases compared to controls using multivariable Cox regression models. RESULTS: CRSsNP (n = 3612) cases were at greater risk (HR, 95% confidence interval) than controls for incidence of: upper airway diseases, including adenotonsillitis (3.29, 2.41-4.50); lower aerodigestive tract diseases, including asthma (2.69, 2.14-3.38); epithelial conditions, including atopic dermatitis (2.75, 1.23-6.16); and hypertension (1.38, 1.19-1.61). CRSwNP (n = 241) cases were at greater risk for obesity than controls (1.74, 1.08-2.80), but CRSwNP was not associated with other diseases. CONCLUSION: The risk of other diseases associated with CRS adds to the burden of an already highly burdensome condition, and suggests either that CRS promotes onset of other diseases or is an indicator of systemic disease processes. Different patterns of association with diseases by CRS phenotype may be due to CRSwNP sample size limitations or reflect a different pattern of disease onset by phenotype. These findings have implications for screening guidelines and care of CRS patients.","description":"Study suggests either that chronic rhinosinusitis promotes onset of other diseases or is an indicator of systemic disease processes.","keywords":["Asthma","General Cardiology","Infectious Disease","Obesity"],"datePublished":"2015-12-01","url":"https://www.sutterhealth.org/research/publications/risk-of-incident-disease-after-dx-of-chronic-rhinosinusitis-1055312747","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"DOI","value":"10.1111/all.12759"}],"sameAs":["https://doi.org/10.1111/all.12759"],"isPartOf":{"@type":"Periodical","name":"Allergy"},"author":[{"@type":"Person","name":"Hirsch AG"},{"@type":"Person","@id":"https://www.sutterhealth.org/research/investigators/xiaowei-sherry-yan-phd-1049681042","name":"Yan XS","url":"https://www.sutterhealth.org/research/investigators/xiaowei-sherry-yan-phd-1049681042"},{"@type":"Person","name":"Sundaresan AS"},{"@type":"Person","name":"Tan BK"},{"@type":"Person","name":"Schleimer RP"},{"@type":"Person","name":"Kern RC"},{"@type":"Person","name":"Kennedy TL"},{"@type":"Person","name":"Greene JS"},{"@type":"Person","name":"Schwartz BS"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Asthma","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Asthma%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"General Cardiology","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22General+Cardiology%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Infectious Disease","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Infectious+Disease%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Obesity","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Obesity%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/risk-of-incident-disease-after-dx-of-chronic-rhinosinusitis-1055312747","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/risk-of-incident-disease-after-dx-of-chronic-rhinosinusitis-1055312747#breadcrumblist"}}} ```