--- title: "Synovial chondromatosis of the ankle. | Sutter Health" description: "Report 2 patients with 23 and 126 loose bodies of the ankle, respectively, who had successful outcomes without malignancy, after excision of lesions." url: "https://www.sutterhealth.org/research/publications/synovial-chondromatosis-of-the-ankle-1055312460" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Synovial chondromatosis of the ankle. # Synovial chondromatosis of the ankle: report of two cases with 23 and 126 loose bodies. Saxena A & St Louis M. _J Foot Ankle Surg. pii: S1067-2516(16)00130-7. doi: 10.1053/j.jfas.2016.02.009. \[Epub ahead of print\]_ 2016-04-05 ## Abstract Synovial chondromatosis is rare joint disorder that has no clear etiology. Classification of the disorder was first reported by Milgram in 1977. One possible cause is a change in the level of fibroblast growth receptor factor receptor-3, which leads to a possible feedback loop that results in the formation of loose bodies. Genetics is another possible cause for the disorder. Synovial chondromatosis is considered benign but does the have the potential for malignant transformation. We report the case of 2 patients with 23 and 126 loose bodies of the ankle, respectively, who had successful outcomes without malignancy, after excision of the lesions. Also presented is a review of the published data for the possible causes of synovial chondromatosis and the symptoms leading up to the transformation from benign to malignant. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/27066867) ## Research topics - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) - [Musculoskeletal Disorders](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Musculoskeletal+Disorders%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Association of short-term complications with procedures through separate incisions during total ankle replacement.](https://www.sutterhealth.org/research/publications/short-term-complications-sep-incisions-tar-1055312445) Criswell B, Hunt K, Kim T, Chou L, Haskell A. Foot Ankle Int. pii: 1071100716651964. \[Epub ahead of print\] 2016 Jun 08 - Publication ### [An Internet-based risk- and stage-tailored osteoporotic fracture risk management program: Effect on knowledge, attitudes and behaviors](https://www.sutterhealth.org/research/publications/osteoporotic-fracture-risk-management-program-1055312543) Drieling RL, Ma J, Thiyagarajan S, Stafford RS. J Women's Health (Larchmt). 20(12):1895-907. doi: 10.1089/jwh.2010.2515. Epub 2011 Oct 4. 2011 Dec 01 - Publication ### [Birth and evolution of chiselling and drilling techniques for removing ear canal exostoses.](https://www.sutterhealth.org/research/publications/chiseling-drilling-techniques-remove-ear-exostoses-1055312313) Mudry A, Hetzler D. 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Epub 2015 Jul 9. 2015 Nov 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/synovial-chondromatosis-of-the-ankle-1055312460#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Synovial chondromatosis of the ankle."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/synovial-chondromatosis-of-the-ankle-1055312460#medicalscholarlyarticle","name":"Synovial chondromatosis of the ankle: report of two cases with 23 and 126 loose bodies.","headline":"Synovial chondromatosis of the ankle.","abstract":"Synovial chondromatosis is rare joint disorder that has no clear etiology. 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