--- title: "Two-yr wt-loss maintenance in diabetes program. | Sutter Health" description: "This study shows sustained benefits of the two primary care-based, technology-mediated DPP lifestyle interventions. The findings warrant replication in long-term studies involving diverse populations." url: "https://www.sutterhealth.org/research/publications/two-yr-wt-loss-maintenance-in-diabetes-program-1055312744" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Two-yr wt-loss maintenance in diabetes program. # Two-year weight-loss maintenance in primary care-based Diabetes Prevention Program lifestyle interventions. Xiao L, Yank V, Wilson SR, Lavori PW, & Ma J. _Nutr Diabetes. 3:e76. doi: 10.1038/nutd.2013.17._ 2013-06-24 ## Abstract Objective: To investigate whether the effects on weight loss and cardiometabolic risk factor reduction of two technology-mediated lifestyle interventions for 15 months in a primary care-based translation trial sustained at 24 months (that is, 9 months after the end of intervention). Design: This study analyzed data from an extended follow-up of participants in the original 'E-LITE' (Evaluation of Lifestyle Interventions to Treat Elevated Cardiometabolic Risk in Primary Care)-randomized controlled trial, which demonstrated the effectiveness of two adapted Diabetes Prevention Program (DPP) lifestyle interventions compared with usual primary care. Subjects: E-LITE randomized 241 overweight or obese participants with pre-diabetes and/or metabolic syndrome to receive usual care alone (n=81) or usual care plus a coach-led (n=79) or self-directed intervention (n=81). The interventions provided coach-led group behavioral weight-loss treatment or a take-home, self-directed DVD using the same 12-week curriculum, followed by 12 additional months of technology-mediated coach contact and self-monitoring support. Participants received no further intervention after month 15. A blinded assessor conducted 24-month visits by following the measurement protocols of the original trial. Measurements include weight and cardiometabolic risk factors (waist circumference, fasting plasma glucose, resting blood pressure, triglycerides, high- and low-density lipoprotein cholesterol, total cholesterol and triglyceride to high-density lipoprotein cholesterol ratio). Results: At month 24, mean±s.e. changes in body mass index (trial primary outcome) and weight (kg) from baseline were -1.9±0.3 (P=0.001) and -5.4±0.9 (P<0.001) in the coach-led intervention, and -1.6±0.3 (P=0.03) and -4.5±0.9 (P=0.001) in the self-directed intervention, compared with -0.9±0.3 and 2.4±0.9 in the usual care group. In addition, both interventions led to a greater percentage of participants maintaining ?7% weight loss and sustained improvements in waist circumference and fasting plasma glucose levels than usual care. Conclusion: This study shows sustained benefits of the two primary care-based, technology-mediated DPP lifestyle interventions. The findings warrant replication in long-term studies involving diverse populations. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/23797383) ## Research topics - [Diabetes, Insulin Resistance and Metabolic Syndrome](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Diabetes%2C+Insulin+Resistance+and+Metabolic+Syndrome%5C%22%22) - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) - [Health Services](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Health+Services%5C%22%22) - [Obesity](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Obesity%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Baseline reach and adoption characteristics in a randomized controlled trial of two weight loss interventions translated into primary care: A structured report of real-world applicability](https://www.sutterhealth.org/research/publications/weight-loss-interventions-translated-into-pc-1055312588) Yank V, Stafford RS, Rosas LG, Ma J. Contemp Clin Trials. 34(1):126-35. doi: 10.1016/j.cct.2012.10.007. Epub 2012 Oct 31. 2013 Jan 01 - Publication ### [Short-term weight loss patterns, baseline predictors, and longer-term follow-up within a randomized controlled trial.](https://www.sutterhealth.org/research/publications/short-term-wt-loss-patterns-in-dpp-intervention-1055312751) Yank V, Xiao L, Wilson SR, Stafford RS, Rosas LG, Ma J. Obesity (Silver Spring). 22(1):45-51. doi: 10.1002/oby.20510. Epub 2013 Oct 15. 2014 Jan 01 - Publication ### [Barriers and facilitators to real-world implementation of the Diabetes Prevention Program in large healthcare systems: lifestyle coach perspectives.](https://www.sutterhealth.org/research/publications/barriers-facilitators-diabetes-prev-program-implementation-1055312731) Halley MC, Petersen J, Nasrallah C, Szwerinski N, Romanelli R, Azar KMJ. J Gen Intern Med. doi: 10.1007/s11606-020-05744-y. \[Epub ahead of print\] 2020 Apr 06 - Publication ### [Translating an evidence-based lifestyle intervention program into primary care: lessons learned.](https://www.sutterhealth.org/research/publications/translate-lifestyle-program-in-primary-care-1055312592) Blonstein AC, Yank V, Stafford RS, Wilson SR, Rosas LG, Ma J. Health Promot Pract. 14(4):491-7. doi: 10.1177/1524839913481604. Epub 2013 Mar 28. 2013 Jul 01 - Publication ### [Comparative effectiveness of early versus delayed metformin in the treatment of type 2 diabetes.](https://www.sutterhealth.org/research/publications/early-vs-delayed-metformin-type-2-diabetes-1055312946) Romanelli RJ, Chung S, Pu J, Nimbal V, Zhao B, Palaniappan L. Diabetes Res Clin Pract. pii: S0168-8227(15)00046-7. doi: 10.1016/j.diabres.2014.12.019. \[Epub ahead of print\] 2015 Jan 21 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/two-yr-wt-loss-maintenance-in-diabetes-program-1055312744#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Two-yr wt-loss maintenance in diabetes program."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/two-yr-wt-loss-maintenance-in-diabetes-program-1055312744#medicalscholarlyarticle","name":"Two-year weight-loss maintenance in primary care-based Diabetes Prevention Program lifestyle interventions.","headline":"Two-yr wt-loss maintenance in diabetes program.","abstract":"Objective: To investigate whether the effects on weight loss and cardiometabolic risk factor reduction of two technology-mediated lifestyle interventions for 15 months in a primary care-based translation trial sustained at 24 months (that is, 9 months after the end of intervention). Design: This study analyzed data from an extended follow-up of participants in the original 'E-LITE' (Evaluation of Lifestyle Interventions to Treat Elevated Cardiometabolic Risk in Primary Care)-randomized controlled trial, which demonstrated the effectiveness of two adapted Diabetes Prevention Program (DPP) lifestyle interventions compared with usual primary care. Subjects: E-LITE randomized 241 overweight or obese participants with pre-diabetes and/or metabolic syndrome to receive usual care alone (n=81) or usual care plus a coach-led (n=79) or self-directed intervention (n=81). The interventions provided coach-led group behavioral weight-loss treatment or a take-home, self-directed DVD using the same 12-week curriculum, followed by 12 additional months of technology-mediated coach contact and self-monitoring support. Participants received no further intervention after month 15. A blinded assessor conducted 24-month visits by following the measurement protocols of the original trial. Measurements include weight and cardiometabolic risk factors (waist circumference, fasting plasma glucose, resting blood pressure, triglycerides, high- and low-density lipoprotein cholesterol, total cholesterol and triglyceride to high-density lipoprotein cholesterol ratio). Results: At month 24, mean±s.e. changes in body mass index (trial primary outcome) and weight (kg) from baseline were -1.9±0.3 (P=0.001) and -5.4±0.9 (P\u003c0.001) in the coach-led intervention, and -1.6±0.3 (P=0.03) and -4.5±0.9 (P=0.001) in the self-directed intervention, compared with -0.9±0.3 and 2.4±0.9 in the usual care group. In addition, both interventions led to a greater percentage of participants maintaining ?7% weight loss and sustained improvements in waist circumference and fasting plasma glucose levels than usual care. Conclusion: This study shows sustained benefits of the two primary care-based, technology-mediated DPP lifestyle interventions. The findings warrant replication in long-term studies involving diverse populations.","description":"This study shows sustained benefits of the two primary care-based, technology-mediated DPP lifestyle interventions. 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