--- title: "Use self-regulation to improve beh change in mood & wt loss. | Sutter Health" description: "Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomes." url: "https://www.sutterhealth.org/research/publications/use-self-regulation-1055312341" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Use self-regulation to improve beh change in mood & wt loss. # The ENGAGE study: Integrating neuroimaging, virtual reality and smartphone sensing to understand self-regulation for managing depression and obesity in a precision medicine model. Williams LM, Pines A, Goldstein-Piekarski AN, Rosas LG, Kullar M, Sacchet MD, Gevaert O, Bailenson J, Lavori PW, Dagum P, Wandell B, Correa C, Greenleaf W, Suppes T, Perry LM, Smyth JM, Lewis MA, Venditti EM, Snowden M, Simmons JM, & Ma J. _Behav Res Ther. pii: S0005-7967(17)30202-4. doi: 10.1016/j.brat.2017.09.012. \[Epub ahead of print\]_ 2017-10-07 ## Abstract Precision medicine models for personalizing achieving sustained behavior change are largely outside of current clinical practice. Yet, changing self-regulatory behaviors is fundamental to the self-management of complex lifestyle-related chronic conditions such as depression and obesity - two top contributors to the global burden of disease and disability. To optimize treatments and address these burdens, behavior change and self-regulation must be better understood in relation to their neurobiological underpinnings. Here, we present the conceptual framework and protocol for a novel study, "Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomes (ENGAGE)". The ENGAGE study integrates neuroscience with behavioral science to better understand the self-regulation related mechanisms of behavior change for improving mood and weight outcomes among adults with comorbid depression and obesity. We collect assays of three self-regulation targets (emotion, cognition, and self-reflection) in multiple settings: neuroimaging and behavioral lab-based measures, virtual reality, and passive smartphone sampling. By connecting human neuroscience and behavioral science in this manner within the ENGAGE study, we develop a prototype for elucidating the underlying self-regulation mechanisms of behavior change outcomes and their application in optimizing intervention strategies for multiple chronic diseases. [PubMed abstract](https://www.ncbi.nlm.nih.gov/pubmed/29074231) ## Research topics - [Health Services](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Health+Services%5C%22%22) - [Mental Health](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Mental+Health%5C%22%22) - [Obesity](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Obesity%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [A conceptual model of the role of complexity in the care of patients with multiple chronic conditions.](https://www.sutterhealth.org/research/publications/complexity-in-the-care-of-pts-with-chronic-conds-1055312633) Grembowski D, Schaefer J, Johnson KE, Fischer H, Moore SL, Tai-Seale M, Ricciardi R, Fraser JR, Miller D, LeRoy L; AHRQ MCC Research Network. Med Care. 52 Suppl 3:S7-S14. doi: 10.1097/MLR.0000000000000045. 2014 Mar 01 - Publication ### [Assessing the impact of behavioral risk factors and known-groups validity of the SF-12 in a US Chinese immigrant population.](https://www.sutterhealth.org/research/publications/beh-risk-factors-sf-12-validity-chinese-immigrants-1055312973) Hung DY, Lubetkin EI, Fahs MC, Shelley DR. Med Care. 47(2):262-7. doi: 10.1097/MLR.0b013e3181844de4. 2009 Feb 01 - Publication ### [Research Aimed at Improving Both Mood and Weight (RAINBOW) in Primary Care: A Type 1 hybrid design randomized controlled trial.](https://www.sutterhealth.org/research/publications/research-aimed-at-improving-both-mood-and-wt-1055312852) Ma J, Yank V, Lv N, Goldhaber-Fiebert JD, Lewis MA, Kaye Kramer M, Snowden MB, Rosas LG, Xiao L, Blonstein AC. Contemp Clin Trials. 43:260-78. doi: 10.1016/j.cct.2015.06.010. Epub 2015 June 19. 2015 Jul 01 - Publication ### [The Electronic CardioMetabolic Program (eCMP) for patients with cardiometabolic risk: a randomized controlled trial.](https://www.sutterhealth.org/research/publications/electronic-cardiometabolic-program-1055312305) Azar KM, Koliwad S, Poon T, Xiao L, Lv N, Griggs R, Ma J. J Med Internet Res. 18(5):e134. doi: 10.2196/jmir.5143. 2016 May 27 - Publication ### [Psychotropic medication discussions in older adults' primary care office visits: So much to do, so little time.](https://www.sutterhealth.org/research/publications/psychotropic-med-discussions-in-older-adults-in-pc-1055312596) Ahn S, Tai-Seale M, Huber C Jr, Smith ML, Ory MG. Aging Ment Health. 15(5):618-29. doi: 10.1080/13607863.2010.548055. 2011 Jul 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/use-self-regulation-1055312341#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Use self-regulation to improve beh change in mood & wt loss."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/use-self-regulation-1055312341#medicalscholarlyarticle","name":"The ENGAGE study: Integrating neuroimaging, virtual reality and smartphone sensing to understand self-regulation for managing depression and obesity in a precision medicine model.","headline":"Use self-regulation to improve beh change in mood & wt loss.","abstract":"Precision medicine models for personalizing achieving sustained behavior change are largely outside of current clinical practice. Yet, changing self-regulatory behaviors is fundamental to the self-management of complex lifestyle-related chronic conditions such as depression and obesity - two top contributors to the global burden of disease and disability. To optimize treatments and address these burdens, behavior change and self-regulation must be better understood in relation to their neurobiological underpinnings. Here, we present the conceptual framework and protocol for a novel study, \"Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomes (ENGAGE)\". The ENGAGE study integrates neuroscience with behavioral science to better understand the self-regulation related mechanisms of behavior change for improving mood and weight outcomes among adults with comorbid depression and obesity. We collect assays of three self-regulation targets (emotion, cognition, and self-reflection) in multiple settings: neuroimaging and behavioral lab-based measures, virtual reality, and passive smartphone sampling. By connecting human neuroscience and behavioral science in this manner within the ENGAGE study, we develop a prototype for elucidating the underlying self-regulation mechanisms of behavior change outcomes and their application in optimizing intervention strategies for multiple chronic diseases.","description":"Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomes.","keywords":["Health Services","Mental Health","Obesity"],"datePublished":"2017-10-07","url":"https://www.sutterhealth.org/research/publications/use-self-regulation-1055312341","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"PMID","value":"29074231"},{"@type":"PropertyValue","propertyID":"DOI","value":"10.1016/j.brat.2017.09.012"}],"sameAs":["https://pubmed.ncbi.nlm.nih.gov/29074231/","https://doi.org/10.1016/j.brat.2017.09.012"],"isPartOf":{"@type":"Periodical","name":"Behav Res Ther"},"author":[{"@type":"Person","name":"Williams LM"},{"@type":"Person","name":"Pines A"},{"@type":"Person","name":"Goldstein-Piekarski AN"},{"@type":"Person","name":"Rosas LG"},{"@type":"Person","name":"Kullar M"},{"@type":"Person","name":"Sacchet MD"},{"@type":"Person","name":"Gevaert O"},{"@type":"Person","name":"Bailenson J"},{"@type":"Person","name":"Lavori PW"},{"@type":"Person","name":"Dagum P"},{"@type":"Person","name":"Wandell B"},{"@type":"Person","name":"Correa C"},{"@type":"Person","name":"Greenleaf W"},{"@type":"Person","name":"Suppes T"},{"@type":"Person","name":"Perry LM"},{"@type":"Person","name":"Smyth JM"},{"@type":"Person","name":"Lewis MA"},{"@type":"Person","name":"Venditti EM"},{"@type":"Person","name":"Snowden M"},{"@type":"Person","name":"Simmons JM"},{"@type":"Person","name":"Ma J"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Health Services","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Health+Services%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Mental Health","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Mental+Health%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Obesity","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Obesity%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/use-self-regulation-1055312341","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/use-self-regulation-1055312341#breadcrumblist"}}} ```