New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

Choquet H, Yin J, Jacobson AS, Horton BH, Hoffmann TJ, Jorgenson E, Avins AL, Pressman AR, Commun Biol.4(1):864. doi: 10.1038/s42003-021-02356-y., 2021 Jul 22

Abstract

Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS1, PBRM1, and SLC25A21) specific to women. This large multiethnic migraine study provides important information that may substantially improve our understanding of the etiology of migraine susceptibility.

Pubmed Abstract

Pubmed AbstractOpens New Window

Associated Topics

Related Publications

Conducting a pilot randomized controlled trial of community-based mindfulness-based stress reduction versus usual care for moderate-to-severe migraine: protocol for the Mindfulness and Migraine Study (M&M).

Pressman A, Law H, Stahl R, Scott A, Jacobson A, Dean L, Sudat S, Obillo A, Avins A.
Trials 2019;20:257.
2019 May 06

Prevalence of migraine in a diverse community--electronic methods for migraine ascertainment in a large integrated health plan.

Pressman A, Jacobson A, Eguilos R, Gelfand A, Huynh C, Hamilton L, Avins A, Bakshi N, Merikangas K.
Cephalalgia. 36(4):325-34. doi: 10.1177/0333102415590242. Epub 2015 Jun 11.
2016 Apr 01

Treatment of refractory chronic demyelinating polyneuropathy with lymphoid irradiation.

Rosenberg NL, Lacy JR, Kennaugh RC, Holers VM, Neville HE, Kotzin BL.
Muscle Nerve. 8(3):223-32.
1985 Mar 01

Interferon beta-1a in children with multiple sclerosis is well tolerated.

Waubant E, Hietpas J, Stewart T, Dyme Z, Herbert J, Lacy J, Miller C, Rensel M, Schwid S, Goodkin D.
Neuropediatrics. 32(4):211-3.
2001 Aug 01

Identification of short-term pharmacodynamic effects of interferon-beta-1a in multiple sclerosis subjects with broad- based phenotypic profiling.

Kantor AB, Deng J, Waubant E, Lin H, Becker CH, Lacy JR, Perrone AM, Bennett D, Goelz SE.
J Neuroimmunol. 188(1-2):103-16. Epub 2007 Jul 5.
2007 Aug 01