Tai-Seale M, Wilson CJ, Stone A, Durbin M, Luft HS., Med Care. 52 Suppl 3:S110-7. doi: 10.1097/MLR.0000000000000023., 2014 Mar 01
BACKGROUND: A national strategic framework to address multiple chronic conditions has called for further research on disease trajectories of patients with comorbidities.
METHODS: An observational study using multilevel models to analyze electronic health record data from a multispecialty practice from 2003 to 2010 to examine disease trajectories of patients with at least 2 of 3 common chronic conditions: overweight/obese, hypertension, and depression. Using longitudinal data on up to 110,000 patients, the effects of comorbidities on the probability of having a diagnosis for overweight/obesity or hypertension and on the trajectories of body mass index (BMI) and blood pressure (BP) over time were examined.
RESULTS: From 2003 to 2010, the percentage of patients with high BMI receiving an overweight/obesity diagnosis grew from 5.0% to 18.7%, and the percentage of patients with high BP having a hypertension diagnosis rose from 39.9% to 51.7%. The effect of time for patients with high BMI and depression was less than the effect of time for high BMI only patients (P<0.01) in receiving overweight/obesity diagnoses. Co-occurring depression and high BMI was positively associated with BMI trajectory (coefficient=0.06, P<0.01), whereas high BP and high BMI (coefficient=-0.07, P<0.01) or high BP and high BMI and depression (coefficient=-0.05, P<0.01) were negatively associated with BMI trajectories.
CONCLUSIONS: Although physicians' recording of diagnoses for patients with high BMI and high BP has improved, significant gaps remain. Some co-occurrence patterns of these 3 conditions not only affected the recognition of overweight/obesity and hypertension over time, but also BMI trajectories over time. Quality improvement efforts should target patients with co-occurring depression and overweight/obesity.