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Histotripsy for Liver Tumors: Treating Without Surgery


October 1, 2026Contributors: Casey J. Ward, M.D., Brian K. Bronzo, M.D.

Histotripsy treats liver tumors or masses for which there were otherwise no options, and it is FDA approved for any lesion in the liver. Sutter Health was one of the first places in the country to get one of these machines. Dr. Casey Ward describes the cases it is for: things that are inside the liver, very high up, next to very critical structures where the alternative would be a transplant or a big liver resection. Patients come with benign liver lesions, such as an adenoma, and with metastatic cancers. About 10 years ago, the University of Michigan found that turning an ultrasound up very high makes tiny bubbles that shear tissue while leaving the critical structures around it intact. The care team can 3D map your tumor, so the surgeon knows where the blood vessels are, where the bile ducts are, and can treat the tumor with a little bit of a margin. Each ablation takes about 20 minutes per tumor, so the whole procedure can take anywhere from about 45 minutes to an hour, depending on how many tumors a patient has. Patients go home about an hour or two after the procedure. At CPMC, the surgeons and the interventional radiologists do it together, so a patient for whom histotripsy is not the right answer can still be connected to the rest of the treatment care that Sutter offers. Chapters 0:00 What histotripsy treats 0:34 How focused ultrasound breaks down a tumor 1:00 How long the procedure takes and going home 1:22 What is known about safety so far 1:39 Surgeons and interventional radiologists together To learn more about histotripsy and liver tumor care at Sutter Health, visit https://www.sutterhealth.org/services/liver-bile-duct-cancer. This video is educational and is not a substitute for professional medical advice. #Histotripsy #LiverTumors #CancerTreatment

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