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Investigator Edward Holt, MD

Edward Holt, MD

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Dr. Holt is a transplant hepatologist at California Pacific Medical Center who specializes in liver transplantation, general hepatology and nonalcoholic fatty liver disease (NAFLD).

At CPMC, he serves as the director of the Fatty Liver Program and the Associate Program Director of the gastroenterology fellowship.

After graduating from Princeton University in 1999, Dr. Holt attended medical school at the Medical University of South Carolina in Charleston. He completed his residency in internal medicine at the Massachusetts General Hospital. Subsequently, Dr. Holt completed fellowships in gastroenterology and transplant hepatology in 2012 and 2013, both at CPMC.

Dr. Holt’s research interest is in nonalcoholic steatohepatitis (NASH), including as principal investigator for both investigator-initiated and industry-sponsored trials. Dr. Holt has maintained a CPMC NAFLD cohort since 2013, and has been an investigator in eight prospective NASH clinical trials since 2014. Dr. Holt also works to increase awareness and education about NAFLD and NASH among primary care providers and patients in the community.


Sutter Health Research Enterprise
2340 Clay Street
3rd Floor
San Francisco, CA, 94115
(415) 600-1020  
HoltE@sutterhealth.org

Primary Research Interests

  • Liver Diseases and Transplant
  • Primary Biliary Cholangitis (PBC)
  • Primary Sclerosing Cholangitis (PSC)

Related Clinical Trials

ASSURE

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC)

Investigators: Edward Holt MD, Raphael Merriman MD, Kidist Yimam MD

Status: Active, Recruiting

ELATIVE

Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) (ELATIVE)

Investigators: Edward Holt MD, Raphael Merriman MD, Kidist Yimam MD

Status: Active, Recruiting

InFUSE

Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE)

Investigators: Todd Frederick M.D., Edward Holt MD, Raphael Merriman MD

Status: Active, Recruiting

MIRUM

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) (VIST

Investigators: Edward Holt MD, Raphael Merriman MD, Kidist Yimam MD

Status: Active, Recruiting

Pliant

Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)

Investigators: Edward Holt MD, Kidist Yimam MD

Status: Active, Recruiting

PRIMIS

Safety, Tolerability, and Efficacy of Cilofexor in Non-Cirrhotic Adults With Primary Sclerosing Cholangitis (PRIMIS)

Investigators: Edward Holt MD, Kidist Yimam MD

Status: Active, Not Recruiting

RESPONSE

RESPONSE: Response to Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Control to or an Intolerance to Ursodeoxycholic Acid (UDCA

Investigators: Edward Holt MD, Raphael Merriman MD, Kidist Yimam MD

Status: Active, Recruiting

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