Rash, memory loss, muscle weakness, neuropathy, and liver problems are the most common recognized side effects. The incidence of these side effects can be as high as 30 percent in real world studies. Most symptoms are mild and can be managed by your medical doctor. A thorough risk, benefits, and alternatives discussion should take place with your medical doctor.
One the issues to remember is interaction of statins with other medications, either Rx (particularly secondary cholesterol-lowering medications, antibiotics, antidepressants, immunosuppressive drugs) or over-the-counter drugs or supplements. Make sure you tell your doctor about any dietary changes or herbal medications you are taking.
Strategies for mitigating side effects of statin therapy include: Taking a brief break from statin therapy; switching to another drug; changing the dose; considering alternatives to statins (like cholesterol absorption blockers like Zetia); and taking coenzyme supplements. Be sure to discuss these options with your physician.