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Investigator Alice R. Pressman, Ph.D., M.S.

Alice R. Pressman, Ph.D., M.S.

 

Dr. Pressman co-directs Sutter Health’s Center for Health Systems Research (East Campus, currently operating as Sutter's Research Development and Dissemination). She also is an epidemiologist and biostatistician specializing in evaluation methodology, clinical trials methods, health disparities, health systems evaluation, and chronic pain research (including migraine and low back pain).

She has 30 years’ experience as a principal investigator, co-investigator, and biostatistician for clinical and epidemiologic research studies in diverse settings including academia, community-based research institutes, and healthcare systems.  Her research has been funded by the National Institutes of Health (NHLBI, NINDS, NIAID, and NCCIH), the Patient Centered Outcomes Research Institute, and various universities, foundations and pharmaceutical companies.  

She also serves as a consulting methodologist for the Palo Alto Medical Foundation and the Sutter system, focusing on complex, multi-organization-sourced data, and clinical and pragmatic trial design.

She leads an Evaluation as a Service (EaaS) program for Sutter Health, which includes development of a rapid and continuous learning evaluation protocol for new system-wide care models. This program provides researchers, clinicians, staff and policy makers at Sutter with tools and data to make decisions about the dissemination of new care models. 

Dr. Pressman received a master’s degree in statistics from the University of Wisconsin, and a Ph.D. in epidemiology from the University of California, Berkeley.


Sutter Health Research Enterprise
2121 N. California Ave, Suite 310
Walnut Creek, CA, 94596
(925) 287-4018  
PressmAR@sutterhealth.org

Primary Research Interests

  • Aging and Longevity
  • Arthritis
  • Biostatistics
  • Breast Cancer
  • COVID-19
  • Cancer
  • Cardiovascular Diseases
  • Comparative Effectiveness
  • Complementary Therapies
  • Crohn's Disease
  • Diabetes Type 2
  • Diabetes, Insulin Resistance and Metabolic Syndrome
  • Digestive Disorders
  • Disease Management
  • EHR Data
  • Food and Nutrition
  • Genetics
  • Health Disparities
  • Health Policy
  • Health Services
  • Infectious Disease
  • Kidney Disease
  • Maternal and Infant Health
  • Medical Informatics
  • Men's Health
  • Mental Health
  • Migraine
  • Musculoskeletal Disorders
  • Neurological Disorders
  • Obesity
  • Ovarian Cancer
  • Pain
  • Pharmacoepidemiology
  • Prevention and Health Maintenance
  • Primary Care
  • Quality Improvement
  • Ulcerative Colitis
  • Women's Health

Publications

Conducting a pilot randomized controlled trial of community-based mindfulness-based stress reduction versus usual care for moderate-to-severe migraine: protocol for the Mindfulness and Migraine Study (M&M).

This is the first pragmatic trial in U.S. of mindfulness-based stress reduction for migraine using community classes.

Impact of home-based, patient-centered support for people with advanced illness in an open health system: a retrospective claims analysis of health expenditures, utilization, and quality of care at end of life.

Advanced Illness Management program has a positive impact on inpatient utilization, cost of care, hospice enrollment, and site of death.

Fracture risk tool validation in an integrated healthcare delivery system.

Fracture Risk Calculator tool, using administrative data, may help target at-risk populations for more complete fracture risk assessment.

A comparison of two worlds: How does Bayes hold up to the status quo for the analysis of clinical trials?

Choosing usual-care controls, even when a satisfactory placebo exists, would allow clinicians to capture the value of common non-specific therapeutic benefits.

Should we reconsider the routine use of placebo controls in clinical research?

Choosing usual-care controls, even when a satisfactory placebo exists, would allow clinicians to capture the value of common non-specific therapeutic benefits.

Adherence to placebo and mortality in the Beta Blocker Evaluation of Survival Trial (BEST).

Analyses of the Beta Blocker Evaluation of Survival trial data support a strong association between adherence to placebo study medication and total mortality.

Initiation of osteoporosis treatment after bone mineral density testing.

Despite the strong association between bone mineral density testing and initiating treatment, nearly half the osteoporotic women did not initiate treatment.

Methods for assessing fracture risk prediction models: experience with FRAX in a large integrated health care delivery system.

Multiple methods should be used to evaluate risk tool performance with less reliance on area under the receiver operating characteristics alone.

Effectiveness of a pharmacist-based gout care management programme in a large integrated health plan: results from a pilot study.

Pharmacist-staffed program can effectively and safely lower and maintain uric acid levels in a high percentage of patients with recurrent gout in primary care.

Prevalence and determinants of osteoporosis drug prescription among patients with high exposure to glucocorticoid drugs.

Despite ready availability of bone-specific osteoporosis drugs, few patients with high exposure to glucocorticoid drugs received such therapy.

Patterns of infliximab use among Crohn's disease patients in a community setting.

In a community-based setting infliximab use has steadily increased. Need to determine why a large number of patients discontinued their treatment.

Does the diagnosis of breast or ovarian cancer trigger referral to genetic counseling?

There are missed opportunities for referring patients to genetic counseling among patients with breast and ovarian cancer.

Prevalence of migraine in a diverse community--electronic methods for migraine ascertainment in a large integrated health plan.

Inexpensive, easily applied EHR-based algorithm provides a new opportunity for monitoring changes in migraine prevalence and identifying potential participants.

Measuring health equity for ambulatory care sensitive conditions in a large integrated health care system: the development of an index.

We designed and implemented an index, calculated as the ratio of observed-to-expected encounters, to quantify health inequalities in healthcare systems.

Virtual small groups for weight management: an innovative delivery mechanism for evidence-based lifestyle interventions among obese men.

Virtual small groups may be an effective means of allowing face-to-face group interaction, while overcoming some barriers to access.

Mind the clinical-analytic gap: electronic health records and COVID-19 pandemic response

Lessons learned from the COVID-19 pandemic can result in the formation of collaborative teams: clinical operations, informatics, data analytics, and research.

The migraine signature study: methods and baseline results

Migraine is a common reason for seeking primary and neurology care, but little is documented about who seeks care and factors that explain variation utilization

Effectiveness of a group-based lifestyle change program versus usual care: an electronic health record, propensity score-matched cohort study

This study examines the effectiveness of a CDC and prevention-aligned lifestyle change program relative to usual care in clinical practice.

Recruitment, retention, and adherence in a randomized feasibility trial of mindfulness-based stress reduction for patients with migraine

Increasing evidence demonstrates effectiveness of Mindfulness-Based Stress Reduction (MBSR) for pain-related and functional disorders

The learning health system in crisis: lessons from the novel coronavirus disease pandemic

Advocating for a learning health network that promotes collaboration between health systems, community-based organizatons, and government agencies

Disparities In outcomes among COVID-19 patients In a large health care system In California.

Our study provides real-world evidence that there are racial and ethnic disparities in the presentation of COVID-19.

Early weight loss and treatment response: data from a lifestyle change program in clinical practice.

Percentage weight change at 12 weeks from baseline can serve as a single indicator of nonresponse at the completion of the 12-month lifestyle change program.

Serious mental illness and health-related factors associated with regional emergency department utilization.

Findings indicate heterogeneity in regional utilization patterns among frequent ED utilizers, with mental illness increasing the likelihood of multi-ED use.

Longitudinal weight outcomes from a behavioral lifestyle intervention in clinical practice.

A lifestyle change program in clinical practice is associated with modest weight loss, sustained through 24 months, in setting of cardiometabolic risk factors.

Short-term weight trajectories and long-term weight outcomes from a lifestyle intervention in real-world clinical practice.

With relationship between magnitudes of short- and long-term wt change, individual wt trajectories may be useful in identifying non-responders who need alt tx.

Racial and ethnic disparities in opioid prescribing for long bone fractures at discharge from the emergency department: a cross-sectional analysis of 22 centers from a health care delivery system in Northern California.

Racial and ethnic minority groups with long bone fractures receive similar frequencies of opioid prescriptions at discharge, with a small potency difference.

Research Studies

Antimicrobial Resistant E. coli Before and After California Senate Bill 27 (ARES): A Natural Experiment

Natural experiment: test hypothesis that reductions in antimicrobial drug use in livestock production will be related to reductions in AMR in chicken meat, UTIs

Investigator: Alice R. Pressman Ph.D., M.S.

Evaluation of a Lifestyle Intervention Adopted for Clinical Practice for Diabetes Prevention (ELEVATE-DP)

This study will identify important barriers to and facilitators of translating an efficacious diabetes prevention intervention (Group Lifestyle Balance, GLB)

Investigators: Kristen M.J. Azar R.N., BSN, MSN/MPH, Investigator, Alice R. Pressman Ph.D., M.S., Robert Romanelli Ph.D., MPH, Associate Scientist, Sylvia Sudat PhD

Genetics and Comorbidity of Migraine

Identify common genetic variants for migraine to determine whether there are single nucleotide polymorphisms associated with migraine.

Investigator: Alice R. Pressman Ph.D., M.S.

Major Depressive Disorder

Purpose is to use EHR to understand the management of major depressive disorder in a large healthcare system, to incorporate pt-reported data in care workflow.

Investigators: Kristen M.J. Azar R.N., BSN, MSN/MPH, Investigator, Alice R. Pressman Ph.D., M.S.

Maternal CARE Study

By testing pregnant women's blood samples for COVID-19 antibodies, study team will examine spread of the virus in pregnancy and variations in infection rates.

Investigators: Alice R. Pressman Ph.D., M.S., Gregory J. Tranah Ph.D.

Mindfulness and Migraine: A Randomized Controlled Trial

Conduct a randomized controlled feasibility trial of mindfulness-based stress reduction for patients with moderate-to-severe migraine headache.

Investigators: Alice R. Pressman Ph.D., M.S., Sylvia Sudat PhD

Pilot Project in Applied Artificial Intelligence: Using Machine Learning to Improve the Safety of Hospital Care

Develop and test predictive model identifying emerging sepsis using artificial intelligence, and translate learnings into improved operational criteria.

Investigators: Alice R. Pressman Ph.D., M.S., Sylvia Sudat PhD

Severe Mental Illness and Patterns of Emergency Department Utilization

Purpose is to provide descriptive info for improving health outcomes by identifying a subgroup of high-frequency ER patients who may have severe mental illness.

Investigators: Kristen M.J. Azar R.N., BSN, MSN/MPH, Investigator, Alice R. Pressman Ph.D., M.S.

Transforming Primary and Specialty Care for Inflammatory Bowel Disease

Use healthcare data to personalize the healthcare experience for people with inflammatory bowel disease.

Investigator: Alice R. Pressman Ph.D., M.S.

Using Electronic Health Records to Identify Gaps in Migraine Headache Care: A Step Towards Improving Patient Outcomes

Use EHRs and survey data to characterize migraineurs at Sutter Health by demographic, comorbidity, symptom, and care gap profiles, to see if tx needs are met.

Investigator: Alice R. Pressman Ph.D., M.S.

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