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Liver Diseases and Transplant Research

Hepatology researchers are investigating the cellular and molecular mechanisms underlying hepatitis B, C and other liver diseases. Identifying early molecular or genetic changes - which may be detected before the disease manifests any clinical symptoms - could lead to interventions that reduce the severity of liver disease, or even prevent it from developing. Clinical researchers in the Liver Disease Management and Transplant Program are leading new investigations into hepatitis B and C disease management, hepatoma, hepatitis and HIV co-infection, nonalcoholic steatohepatitis, hepatorenal syndrome, and the care of liver transplant patients.
Liver Diseases and Transplant

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Clinical Trials

InFUSE

STATUS: Active, Recruiting

Viking NASH

STATUS: Active, Recruiting

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Publications

Factors associated with prevalence and treatment of primary biliary cholangitis in United States health systems.

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation.

Increasing prevalence of primary biliary cholangitis and reduced mortality with treatment.

Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture.

Ursodeoxycholic acid treatment preferentially improves overall survival among African Americans with primary biliary cholangitis.

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Featured Investigator

Edward Holt

Edward Holt

MD

Meet Edward Holt

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